The course describes the medicinal chemistry of an important class of drugs that act on the CNS. The therapeutic agents that are used to treat many of the CNS-based disorders shall be studied such as antipsychotic agents, sedatives, hypnotics, antidepressants, analgesics and general anesthetics. General information and dangers of drug abuse shall be illustrated. The course will expose the students to the study of SAR, mechanism of actions and metabolism of these agents.